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optogenetic stimulation  (Thorlabs)

 
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    Thorlabs optogenetic stimulation
    Optogenetic Stimulation, supplied by Thorlabs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/optogenetic+stimulation/pm42285986-231-1-9?v=Thorlabs
    Average 86 stars, based on 1 article reviews
    optogenetic stimulation - by Bioz Stars, 2026-07
    86/100 stars

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    Image Search Results


    A) Voltage traces from (i) stellate, (ii) pyramidal, and (iii) fast-spiking interneurons during optogenetic stimulation of CaMKIIα+ neurons. B) Raster plots showing 40 theta periods of sinusoidal 8 Hz optogenetic stimulation for the same recording as A. C) Spike probability histogram for each neuron relative to phase of theta stimulation [mean (solid line) ± S.E.M. (shaded region)]. Example spike probability from neurons shown in A and B (dashed line). D) Interspike firing rate histogram for each neuron [mean (solid line) ± S.E.M. (shaded region)]. Example spike probability from neurons shown in A and B (dashed line).

    Journal: bioRxiv

    Article Title: Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    doi: 10.64898/2026.04.21.719932

    Figure Lengend Snippet: A) Voltage traces from (i) stellate, (ii) pyramidal, and (iii) fast-spiking interneurons during optogenetic stimulation of CaMKIIα+ neurons. B) Raster plots showing 40 theta periods of sinusoidal 8 Hz optogenetic stimulation for the same recording as A. C) Spike probability histogram for each neuron relative to phase of theta stimulation [mean (solid line) ± S.E.M. (shaded region)]. Example spike probability from neurons shown in A and B (dashed line). D) Interspike firing rate histogram for each neuron [mean (solid line) ± S.E.M. (shaded region)]. Example spike probability from neurons shown in A and B (dashed line).

    Article Snippet: For compatibility with the voltage imaging microscope, a 490 nm LED (Thorlabs, M490L4) delivered widefield sinusoidal optogenetic stimulation through a 16x objective lens.

    Techniques:

    A) Example post-synaptic currents recorded during optogenetic stimulation of CaMKIIα+ neurons. From top to bottom: EPSCs from fast-spiking interneuron. IPSCs recorded from stellate, pyramidal, and fast-spiking interneuron. B) Average scalogram of gamma-filtered PSCs from neurons in A. Left: EPSCs from fast-spiking interneuron. Right: IPSCs from pyramidal cell. C) Gamma frequency of PSCs from all neurons. Left: EPSCs from fast-spiking interneurons. Right: IPSCs from stellate, pyramidal, and fast-spiking interneurons. D) Peak gamma power of PSCs from all neurons. Left: EPSCs from fast-spiking interneurons. Right: IPSCs from stellate, pyramidal, and fast-spiking interneurons.

    Journal: bioRxiv

    Article Title: Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    doi: 10.64898/2026.04.21.719932

    Figure Lengend Snippet: A) Example post-synaptic currents recorded during optogenetic stimulation of CaMKIIα+ neurons. From top to bottom: EPSCs from fast-spiking interneuron. IPSCs recorded from stellate, pyramidal, and fast-spiking interneuron. B) Average scalogram of gamma-filtered PSCs from neurons in A. Left: EPSCs from fast-spiking interneuron. Right: IPSCs from pyramidal cell. C) Gamma frequency of PSCs from all neurons. Left: EPSCs from fast-spiking interneurons. Right: IPSCs from stellate, pyramidal, and fast-spiking interneurons. D) Peak gamma power of PSCs from all neurons. Left: EPSCs from fast-spiking interneurons. Right: IPSCs from stellate, pyramidal, and fast-spiking interneurons.

    Article Snippet: For compatibility with the voltage imaging microscope, a 490 nm LED (Thorlabs, M490L4) delivered widefield sinusoidal optogenetic stimulation through a 16x objective lens.

    Techniques:

    A) Example voltage trace of a fast-spiking interneuron (blue) and concurrent LFP (black) during optogenetic stimulation of CaMKIIα+ neurons. B) Filtered gamma frequency LFP component (black) and raster plot of fast-spiking interneuron (blue) from A. C) Resultant vector comparison between stellate (red), pyramidal (green), and fast-spiking interneurons (blue). Left: Individual neurons. Right: Pooled within cell types. D) Pooled gamma spike phase distributions for stellate, pyramidal and fast-spiking interneurons.

    Journal: bioRxiv

    Article Title: Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    doi: 10.64898/2026.04.21.719932

    Figure Lengend Snippet: A) Example voltage trace of a fast-spiking interneuron (blue) and concurrent LFP (black) during optogenetic stimulation of CaMKIIα+ neurons. B) Filtered gamma frequency LFP component (black) and raster plot of fast-spiking interneuron (blue) from A. C) Resultant vector comparison between stellate (red), pyramidal (green), and fast-spiking interneurons (blue). Left: Individual neurons. Right: Pooled within cell types. D) Pooled gamma spike phase distributions for stellate, pyramidal and fast-spiking interneurons.

    Article Snippet: For compatibility with the voltage imaging microscope, a 490 nm LED (Thorlabs, M490L4) delivered widefield sinusoidal optogenetic stimulation through a 16x objective lens.

    Techniques: Plasmid Preparation, Comparison

    A) Example field of view for targeted illumination voltage imaging. Fluorescent neurons express Voltron2. B) Average LFP Scalogram demonstrates strong gamma frequency activity. C) Voltage traces from 41 neurons shown in A and the simultaneous LFP activity. Inset zooms in on traces within dashed rectangle. D) Average spike timing of all neurons in C (n = 41) relative to theta stimulation phase [mean (black) ± S.E.M. (gray)]. Average LFP gamma (blue) lags excitatory neuron spiking oscillations. E) Spike raster plot (black) of all neurons in C (n = 41) during 4 consecutive cycles of 8 Hz optogenetic stimulation. Light stimulus is shown in light blue. Average LFP (blue) and spike histogram [mean (black) ± S.E.M. (gray)] aligned with example theta period using dashed lines. F) Average interspike firing rate histograms per theta stimulation period from neurons in all imaging sessions (n = 240). G) Relationship between spike train correlations of all neurons (n = 240) and pairwise spatial distance. H) Comparison of spike train correlations for all neurons (n = 240) across different theta stimulation frequencies.

    Journal: bioRxiv

    Article Title: Distinct cell-type contributions and network topography of theta-nested gamma oscillations in the medial entorhinal cortex

    doi: 10.64898/2026.04.21.719932

    Figure Lengend Snippet: A) Example field of view for targeted illumination voltage imaging. Fluorescent neurons express Voltron2. B) Average LFP Scalogram demonstrates strong gamma frequency activity. C) Voltage traces from 41 neurons shown in A and the simultaneous LFP activity. Inset zooms in on traces within dashed rectangle. D) Average spike timing of all neurons in C (n = 41) relative to theta stimulation phase [mean (black) ± S.E.M. (gray)]. Average LFP gamma (blue) lags excitatory neuron spiking oscillations. E) Spike raster plot (black) of all neurons in C (n = 41) during 4 consecutive cycles of 8 Hz optogenetic stimulation. Light stimulus is shown in light blue. Average LFP (blue) and spike histogram [mean (black) ± S.E.M. (gray)] aligned with example theta period using dashed lines. F) Average interspike firing rate histograms per theta stimulation period from neurons in all imaging sessions (n = 240). G) Relationship between spike train correlations of all neurons (n = 240) and pairwise spatial distance. H) Comparison of spike train correlations for all neurons (n = 240) across different theta stimulation frequencies.

    Article Snippet: For compatibility with the voltage imaging microscope, a 490 nm LED (Thorlabs, M490L4) delivered widefield sinusoidal optogenetic stimulation through a 16x objective lens.

    Techniques: Imaging, Activity Assay, Comparison